Structure of PDB 7d3e Chain B

Receptor sequence
>7d3eB (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
LGHTFPFYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRGKTRLFW
LLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKAFSSEWISADIGLQV
GLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDP
VLYLAEKFTPRSPCGLYRQYRLAGHYTSAMLWVAFLCWLLANVMLSMPVL
VYGGYMLLATGIFQLLALLFFSMATSLTSPCPLHLGASVLHTHHGPAFWI
TLTTGLLCVLLGLAMAVAHRMQ
3D structure
PDB7d3e Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B Y126 N127 E128 K148 Y123 N124 E125 K145
BS02 MAN B T123 I124 N125 T120 I121 N122
BS03 MAN B E122 T123 Y126 E119 T120 Y123
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0008104 protein localization
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0015031 protein transport
GO:0042743 hydrogen peroxide metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0050727 regulation of inflammatory response
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000609 regulation of thyroid hormone generation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7d3e, PDBe:7d3e, PDBj:7d3e
PDBsum7d3e
PubMed33420071
UniProtQ1HG43|DOXA1_HUMAN Dual oxidase maturation factor 1 (Gene Name=DUOXA1)

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