Structure of PDB 7d3c Chain B

Receptor sequence
>7d3cB (length=299) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
SGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDDTVWCPRHVMCPADQLS
DPNYDALLISMTNHSFSVQKHANLRVVGHAMQGTLLKLTVDVANPSTPAY
TFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGYT
KEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCS
VNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDML
AVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGV
3D structure
PDB7d3c The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H41 F143 G146 S147 C148 H166 M168 E169 Q192 V193 H41 F139 G142 S143 C144 H162 M164 E165 Q188 V189
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7d3c, PDBe:7d3c, PDBj:7d3c
PDBsum7d3c
PubMed23549610
UniProtK9N7C7|R1AB_MERS1 Replicase polyprotein 1ab (Gene Name=rep)

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