Structure of PDB 7cwz Chain B

Receptor sequence
>7cwzB (length=601) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
LAKGEMNLNALFIGDKAENGQLYKDLLIDLVDEHLGWRQNYMPQDMPVIS
SQERTSKSYEKTVNHMKDVLNEISSRMRTHSVPWHTAGRYWGHMNSETLM
PSLLAYNFAMLWNGNNVAYESSPATSQMEEEVGHEFAHLMSYKNGWGHIV
ADGSLANLEGLWYARNIKSLPFAMKEVKPELVAGKSDWELLNMPTKEIMD
LLESAEDEIDEIKAHSARSGKHLQAIGKWLVPQTKHYSWLKAADIIGIGL
DQVIPVPVDHNYRMDINELEKIVRGLAEEQIPVLGVVGVVGSTEEGAVDS
IDKIIALRDELMKDGIYYYVHVDAAYGGYGRAIFLDEDNNFIPYEDLQDV
HEEYGVFKEKKEHISREVYDAYKAIELAESVTIDPHAMGYIPYSAGGIVI
QDIRMRDVISYFIPLGAYILEGSKAGATAASVWAAHHVLPLNVAGYGKLI
GASIEGSHHFYNFLNDLTFKVGDKEIEVHTLTHPDFNMVDYVFKEKGNDD
LVAMNKLNHDVYDYASYVKGNIYNNEFITSHTDFAIPDYGNSPLKFVNSL
GFSDEEWNRAGKVTVLRAAVMTPYMNDKEEFDVYAPKIQAALQEKLEQIY
D
3D structure
PDB7cwz Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis K392A mutant in complex with the cofactor PLP and L-dopa
ChainB
Resolution2.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.-
4.1.1.25: tyrosine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B H526 H548 D550 H509 H531 D533
BS02 PLP B D157 G158 S159 H241 D328 A330 D389 H391 D152 G153 S154 H236 D323 A325 D384 H386
BS03 LDP B H98 N100 Y398 H93 N95 Y393
BS04 LDP B N120 S126 N115 S121
Gene Ontology
Molecular Function
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0004837 tyrosine decarboxylase activity
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036468 L-dopa decarboxylase activity
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:1903184 L-dopa metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7cwz, PDBe:7cwz, PDBj:7cwz
PDBsum7cwz
PubMed
UniProtQ838D6|TYRDC_ENTFA L-tyrosine decarboxylase (Gene Name=tdc)

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