Structure of PDB 7cqt Chain B

Receptor sequence
>7cqtB (length=449) Species: 3707 (Brassica juncea) [Search protein sequence]
AKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELE
DVISMSFNAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFE
KCGNTDVEGVDSTNACYGGTAALLNCVNWVESNSWDGRYGLVICTDSAVY
AEGPARPTGGAAAIAMLIGPDAPIVFESKLRGSHMAHVYDFYKPNLASEY
PVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEFSINDADYFVFHSPYN
KLVQKSFARLLYNDFLRNASSIDEAAEKFTPYSSLSLDESYQSRDLEKVS
QQLAKTYYDAKVQPTTLVPKQVGNMYTASLYAAFASLVHNKHSDLAGKRV
VMFSYGAGSTATMFSLRLCENQSPFSLSNIASVMDVGGKLKARHEYAPEK
FVETMKLMEHRYGAKEFVTSKEGILDLLAPGTYYLKEVDSLYRRFYGKK
3D structure
PDB7cqt Overexpression and Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA Synthase Affect Central Metabolic Pathways in Tobacco.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO B S31 G33 K34 G38 Y151 P155 A156 S209 H247 P249 K252 K256 Y357 S30 G32 K33 G37 Y150 P154 A155 S208 H246 P248 K251 K255 Y355
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0016126 sterol biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7cqt, PDBe:7cqt, PDBj:7cqt
PDBsum7cqt
PubMed33340324
UniProtQ9M6U3

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