Structure of PDB 7cp1 Chain B

Receptor sequence
>7cp1B (length=417) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARR
GAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANL
SGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIV
ADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIP
TQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITG
ERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAV
KAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGF
HALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGY
FDRIATTVDPNSSTTAL
3D structure
PDB7cp1 Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism.
ChainB
Resolution2.58 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y89 D108 D153 E155 H180 E182 C191 H193 R228 E285 Q308 S315 S317
Catalytic site (residue number reindexed from 1) Y88 D107 D152 E154 H179 E181 C190 H192 R227 E284 Q307 S314 S316
Enzyme Commision number 4.1.3.1: isocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ITN B D108 R228 E285 N313 T347 D107 R227 E284 N312 T346
BS02 MG B D108 D153 E155 D107 D152 E154
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity
GO:0016829 lyase activity
GO:0035375 zymogen binding
GO:0046421 methylisocitrate lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0052572 response to host immune response
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7cp1, PDBe:7cp1, PDBj:7cp1
PDBsum7cp1
PubMed33951112
UniProtP9WKK7|ACEA_MYCTU Isocitrate lyase (Gene Name=icl)

[Back to BioLiP]