Structure of PDB 7cp0 Chain B

Receptor sequence
>7cp0B (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
AWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGS
YAARQHIMQRIQRLQADWVLEIDTFLSQTPEGERSFSNIISTLNPTAKRH
LVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTV
SDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARG
TSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLL
KDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDD
NEENLDESTIDNLNKILQVFVLEYLHL
3D structure
PDB7cp0 Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D159 E202 H330 D125 E168 H296
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
GO:0036211 protein modification process
Cellular Component
GO:0005576 extracellular region
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Cellular Component
External links
PDB RCSB:7cp0, PDBe:7cp0, PDBj:7cp0
PDBsum7cp0
PubMed33373636
UniProtQ16769|QPCT_HUMAN Glutaminyl-peptide cyclotransferase (Gene Name=QPCT)

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