Structure of PDB 7cmi Chain B

Receptor sequence
>7cmiB (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
GLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGA
LCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIAL
TFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF
TAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ
GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTA
MSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRL
FFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINY
VGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVF
SLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKM
CVVVYPEV
3D structure
PDB7cmi Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LEU B I53 G55 G57 N134 F243 G246 I13 G15 G17 N94 F203 G206
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015101 organic cation transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015180 L-alanine transmembrane transporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0015190 L-leucine transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015349 thyroid hormone transmembrane transporter activity
GO:0019534 toxin transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042605 peptide antigen binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006865 amino acid transport
GO:0015804 neutral amino acid transport
GO:0015807 L-amino acid transport
GO:0015816 glycine transport
GO:0015820 L-leucine transport
GO:0015827 tryptophan transport
GO:0015829 valine transport
GO:0035524 proline transmembrane transport
GO:0055085 transmembrane transport
GO:0070327 thyroid hormone transport
GO:0089718 amino acid import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903801 L-leucine import across plasma membrane
GO:1904273 L-alanine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cmi, PDBe:7cmi, PDBj:7cmi
PDBsum7cmi
PubMed33298890
UniProtQ9UHI5|LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (Gene Name=SLC7A8)

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