Structure of PDB 7cca Chain B

Receptor sequence
>7ccaB (length=287) Species: 654913 (Shrimp white spot syndrome virus (isolate Tongan)) [Search protein sequence]
MEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLT
TKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYD
RAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDR
RMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPF
NIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPRP
FPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKM
3D structure
PDB7cca Structure analysis of thymidylate synthase from white spot syndrome virus reveals WSSV-specific structural elements.
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E62 W84 Y110 C170 R190 D193
Catalytic site (residue number reindexed from 1) E62 W84 Y110 C170 R190 D193
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B R150 R151 R150 R151
BS02 UMP B R24 C170 H171 R190 S191 G192 D193 N201 H231 Y233 R24 C170 H171 R190 S191 G192 D193 N201 H231 Y233
BS03 MTX B F55 I81 H82 I83 F200 K286 F55 I81 H82 I83 F200 K286
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cca, PDBe:7cca, PDBj:7cca
PDBsum7cca
PubMed33197475
UniProtQ77J90

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