Structure of PDB 7cbk Chain B

Receptor sequence
>7cbkB (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRA
VRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATI
NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS
LCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYP
DAFAPVAQFVNWIDSIIQ
3D structure
PDB7cbk Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 F192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H41 D88 F170 G171 D172 S173
Enzyme Commision number 3.4.21.37: leukocyte elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B Q135 C201 N204 Q121 C179 N180
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7cbk, PDBe:7cbk, PDBj:7cbk
PDBsum7cbk
PubMed32657577
UniProtP08246|ELNE_HUMAN Neutrophil elastase (Gene Name=ELANE)

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