Structure of PDB 7c7i Chain B

Receptor sequence
>7c7iB (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MREYKLVVLGSGGVGKSALTVQFVQGIFVDEYDPTIEDSYRKQVEVDAQQ
CMLEILDTAGTQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQIL
RVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSK
INVNEIFYDLVRQINR
3D structure
PDB7c7i PHENIX: a comprehensive Python-based system for macromolecular structure solution.
ChainB
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B N155 E156 N154 E155
BS02 GTP B G13 V14 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 D57 N116 K117 D119 L120 S147 K149 G13 V14 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 D57 N115 K116 D118 L119 S146 K148
BS03 MG B S17 D33 S17 D33
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase-mediated signal transduction
GO:0008283 cell population proliferation
GO:0017156 calcium-ion regulated exocytosis
GO:0030033 microvillus assembly
GO:0032486 Rap protein signal transduction
GO:0033625 positive regulation of integrin activation
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0051649 establishment of localization in cell
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0099010 modification of postsynaptic structure
GO:1901888 regulation of cell junction assembly
GO:2000114 regulation of establishment of cell polarity
GO:2000301 negative regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0035577 azurophil granule membrane
GO:0045121 membrane raft
GO:0070062 extracellular exosome
GO:0070161 anchoring junction
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c7i, PDBe:7c7i, PDBj:7c7i
PDBsum7c7i
PubMed
UniProtP61224|RAP1B_HUMAN Ras-related protein Rap-1b (Gene Name=RAP1B)

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