Structure of PDB 7c49 Chain B

Receptor sequence

>7c49B (length=424) Species: 1042876 (Pseudomonas putida S16)

GGFDYDVVVVGGGFAGATAARECGLQGYRTLLLEARSRLGGRTFTSRFAG
QEIEFGGAWVHWLQPHVWAEMQRYGLGVVEDPLTNLDKTLIMYNDGSVES
ISPDEFGKNIRIAFEKLCHDAWEVFPRPHEPMFTERARELDKSSVLDRIK
TLGLSRLQQAQINSYMALYAGETTDKFGLPGVLKLFACGGWNYDAFMDTE
THYRIQGGTIGLINAMLTDSGAEVRMSVPVTAVEQVNGGVKIKTDDDEII
TAGVVVMTVPLNTYKHIGFTPALSKGKQRFIKEGQLSKGAKLYVHVKQNL
GRVFAFADEQQPLNWVQTHDYSDELGTILSITIARKETIDVNDRDAVTRE
VQKMFPGVEVLGTAAYDWTADPFSLGAWAAYGVGQLSRLKDLQAATSNGW
HANIDGAVESGLRAGREVKQLLSL

3D structure

• PDB: 7c49 Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
• Chain: B
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 1.4.2.2: nicotine dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	V59 G60 A64 E83 A84 R85 G90 R91 T92 G105 G106 A107 W108 V279 V308 P309 F422 A426 W427 A461 N462 I463 A466	V10 G11 A15 E34 A35 R36 G41 R42 T43 G56 G57 A58 W59 V230 V259 P260 F373 A377 W378 A402 N403 I404 A407
BS02	HNL	B	L217 Y218 T250 W364 T381 W427 A461	L168 Y169 T201 W315 T332 W378 A402

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:7c49, PDBe:7c49, PDBj:7c49
• PDBsum: 7c49
• PubMed: 32873764
• UniProt: F8G0P2|NICA2_PSEP6 Nicotine dehydrogenase (Gene Name=nicA2)