Structure of PDB 7bes Chain B

Receptor sequence
>7besB (length=229) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGG
GNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTA
ITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIG
ADVVLMAKAVDGVFAEDPAELLTAVSHREVLDRGLRVADATAFSLCMDNG
MPILVFNLLTDGNIARAVRGEKIGTLVTT
3D structure
PDB7bes Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.22: UMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP B G38 G39 G76 G77 G78 F81 R82 G83 D97 G100 M101 G157 M158 F163 S164 T165 G11 G12 G49 G50 G51 F54 R55 G56 D70 G73 M74 G130 M131 F136 S137 T138
BS02 UTP B L138 R141 R144 K148 L111 R114 R117 K121
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0044210 'de novo' CTP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bes, PDBe:7bes, PDBj:7bes
PDBsum7bes
PubMed35152545
UniProtP9WHK5|PYRH_MYCTU Uridylate kinase (Gene Name=pyrH)

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