Structure of PDB 7bdj Chain B

Receptor sequence

>7bdjB (length=1722) Species: 9606 (Homo sapiens)

LAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKP
KPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLC
APTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMV
GSFGKRLATYGITVAELTGDHQEEISATQIIVCTPEKWDIITRKGGERTY
TQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATL
PNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMN
EIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREG
SASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKH
IQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGR
AGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEI
VLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLD
LVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLL
KPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEP
SAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVLNRGWA
QLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYD
LNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTIT
PDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFF
VPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQ
PLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSG
KTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKV
VLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDE
VHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDVAHWLG
CSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSP
KKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLS
DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMN
VAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIM
CQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYL
TWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSKCISIE
DEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEY
ENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLS
AELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWS
KDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA
DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPL
FPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYT
LYFMSDAYMGCDQEYKFSVDVK

3D structure

• PDB: 7bdj Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
• Chain: B
• Resolution: 2.59 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TGB	B	F478 L481 N482 Q485 T505 G506 G508 K509 T510 N511 D615 E616	F76 L79 N80 Q83 T103 G104 G106 K107 T108 N109 D210 E211
BS02	TGB	B	F1328 Q1332 T1352 G1353 G1355 K1356 T1357 I1358 D1454 E1455 N1655 P1694	F923 Q927 T947 G948 G950 K951 T952 I953 D1049 E1050 N1250 P1289
BS03	MG	B	K509 D615 E616	K107 D210 E211
BS04	MG	B	K1356 D1454 E1455	K951 D1049 E1050

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:7bdj, PDBe:7bdj, PDBj:7bdj
• PDBsum: 7bdj
• PubMed: 34048711
• UniProt: O75643|U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (Gene Name=SNRNP200)