Structure of PDB 7bam Chain B

Receptor sequence

>7bamB (length=1904) Species: 9606 (Homo sapiens)

METACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQ
VPVSQQNLHSFYDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQVMTSDG
TPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQE
HTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPNPVVSPSPLTSFAS
SCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLTHPT
IPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSE
AFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQS
GILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPV
ALTCGSDGSLYVGDFNYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYYL
ATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLRCGD
GGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIISTLLGSLSCD
SVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPM
HCLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTSGEIS
LVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVAD
LGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTG
DYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTM
GTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLT
NVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQD
QVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPI
DNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYD
DHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSER
MEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLS
SVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYL
GTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCT
IRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLP
IDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEV
QYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQT
VSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYK
MDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKS
SHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGD
EFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHG
GLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKN
NNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELI
HTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSAPKTKKFAS
SGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTI
DGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTR
RYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLR
EGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFM
RQSE

3D structure

• PDB: 7bam Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.
• Chain: B
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	E835 A837 D840 K842 N844 D851	E2 A4 D7 K9 N11 D18
BS02	CA	B	E835 D843 D845 D847 L849 D854	E2 D10 D12 D14 L16 D21
BS03	CA	B	D845 D847 D854 D856	D12 D14 D21 D23

External links

• PDB: RCSB:7bam, PDBe:7bam, PDBj:7bam
• PDBsum: 7bam
• PubMed: 35099835
• UniProt: Q6N022|TEN4_HUMAN Teneurin-4 (Gene Name=TENM4)