Structure of PDB 7b94 Chain B

Receptor sequence
>7b94B (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
ELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPS
GLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEIS
ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRD
VKPSNILVNSRGEIKLCDFGVSGQLIDSMATRSYMSPERLQGTHYSVQSD
IWSMGLSLVEMAVGRYPIGSMAIFELLDYIVNEPPPKLPSGVFSLEFQDF
VNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
3D structure
PDB7b94 Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1) D150 K152 N155 D168 D177 T181
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B G75 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208 G35 V42 A55 K57 M103 M106 S110 Q113 D150 K152 S154 N155 L157 D168
BS02 MG B N195 D208 N155 D168
BS03 T3W B K97 I141 D208 F209 L215 M219 K57 I101 D168 F169 L175 M179
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b94, PDBe:7b94, PDBj:7b94
PDBsum7b94
PubMed33603979
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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