Structure of PDB 7b7v Chain B

Receptor sequence

>7b7vB (length=155) Species: 9606 (Homo sapiens)

RRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEEC
AQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEP
KNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGY
KGNHL

3D structure

• PDB: 7b7v NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.
• Chain: B
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 3.6.1.9: nucleotide diphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	4DG	B	R34 S37 G48 H49 Y92 T94 K116 F135 G137	R25 S28 G39 H40 Y83 T85 K107 F126 G128
BS02	MG	B	G47 E67	G38 E58

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
• GO:0016787 hydrolase activity
• GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
• GO:0044715 8-oxo-dGDP phosphatase activity
• GO:0046872 metal ion binding
• GO:0047429 nucleoside triphosphate diphosphatase activity

Biological Process

• GO:0000278 mitotic cell cycle
• GO:0000302 response to reactive oxygen species
• GO:0006195 purine nucleotide catabolic process
• GO:0006203 dGTP catabolic process
• GO:0009217 purine deoxyribonucleoside triphosphate catabolic process
• GO:0042178 xenobiotic catabolic process
• GO:0042262 DNA protection
• GO:0055086 nucleobase-containing small molecule metabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:1901292 nucleoside phosphate catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7b7v, PDBe:7b7v, PDBj:7b7v
• PDBsum: 7b7v
• PubMed: 34234136
• UniProt: Q9NV35|NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (Gene Name=NUDT15)