Structure of PDB 7b67 Chain B

Receptor sequence
>7b67B (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
PRGRRPGVGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGE
TWEECAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVT
HDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLN
HLVGYKGNH
3D structure
PDB7b67 Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SYW B G17 V18 G19 V40 L47 G50 Y92 Y94 T96 F137 W138 G139 L140 G11 V12 G13 V34 L41 G44 Y86 Y88 T90 F131 W132 G133 L134
External links
PDB RCSB:7b67, PDBe:7b67, PDBj:7b67
PDBsum7b67
PubMed33753169
UniProtQ9NV35|NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (Gene Name=NUDT15)

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