Structure of PDB 7b3m Chain B

Receptor sequence

>7b3mB (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]

LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVS
HKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD
GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI
MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIGMAIFELLDYIVNEPPPKLPSGVFSLE
FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN

3D structure

PDB

7b3m Fragment-Based Discovery of Novel Allosteric MEK1 Binders.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D190 K192 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1)	D154 K156 N159 D172 D181 T186
Enzyme Commision number	2.7.12.2: mitogen-activated protein kinase kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	B	N195 D208	N159 D172
BS02	ANP	B	L74 G75 A76 G77 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208	L38 G39 A40 G41 V46 A59 K61 M107 M110 S114 Q117 D154 K156 S158 N159 L161 D172
BS03	SU5	B	I141 M143 D208 F209 V211 S212 L215 I216	I105 M107 D172 F173 V175 S176 L179 I180

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7b3m, PDBe:7b3m, PDBj:7b3m
PDBsum	7b3m
PubMed	33603979
UniProt	Q02750\|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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