Structure of PDB 7b1g Chain B

Receptor sequence
>7b1gB (length=650) Species: 7955 (Danio rerio) [Search protein sequence]
ELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIA
IENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHFSDFTPDIT
PIILAAHTNNYEIIKMLVQKGVSVPQPHDVDSLRHSRSRLNIYKALASPS
LIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLD
QTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEF
PGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFIC
HTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEI
KQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTW
EMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILK
FLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETL
QSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIA
MMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIAENVRLNH
QYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMM
3D structure
PDB7b1g Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 44E B Y523 R553 Q569 F572 Y455 R485 Q501 F504
BS02 44E B A598 T603 V606 A530 T535 V538
BS03 CA B E417 N435 E349 N367
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b1g, PDBe:7b1g, PDBj:7b1g
PDBsum7b1g
PubMed33236980
UniProtU3N7D8

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