Structure of PDB 7b0s Chain B

Receptor sequence
>7b0sB (length=643) Species: 7955 (Danio rerio) [Search protein sequence]
LSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAI
ENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDIT
PIILAAHTNNYEIIKMLVQKGVSVPQPHEVVDSLRHSRSRLNIYKALASP
SLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLL
DQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDE
RHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASY
LTFLFLLLLASQHIVNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGG
FQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTL
VAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCL
VLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSI
FGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQ
HIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIAENVRLNHQYQEVLRN
LVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMK
3D structure
PDB7b0s Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S9Q B H369 Y373 F413 D438 M441 N442 S488 R491 L495 H296 Y300 F338 D363 M366 N367 S413 R416 L420
BS02 CA B Q420 N435 Q345 N360
BS03 44E B Q569 F572 W573 Q494 F497 W498
BS04 44E B A598 T599 A523 T524
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b0s, PDBe:7b0s, PDBj:7b0s
PDBsum7b0s
PubMed33236980
UniProtU3N7D8

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