Structure of PDB 7apo Chain B

Receptor sequence
>7apoB (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSEL
STKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQ
DTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA
ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRRPHMFPKMLMKITD
LRSISAKGAERVITLKMEIPGSMPPLIQEMLEN
3D structure
PDB7apo Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T233 I237 I258 P408 L409 M413 T52 I56 I77 P225 L226 M230
BS02 EQN B F228 L231 S232 L266 L269 F286 S287 F302 G391 V395 F47 L50 S51 L85 L88 F105 S106 F121 G208 V212 BindingDB: EC50=4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7apo, PDBe:7apo, PDBj:7apo
PDBsum7apo
PubMed33647291
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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