Structure of PDB 7ap9 Chain B

Receptor sequence
>7ap9B (length=1129) Species: 502057 (Vaccinia virus GLV-1h68) [Search protein sequence]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVF
INKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRH
YKISLDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMP
PEVVYLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEF
KYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCH
RILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGL
NHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPVRKYHPSQY
LYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSYY
KDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEVG
ITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTFS
DIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAEF
RDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLMY
PERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQR
GGLDIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLVRLNAFLESGD
AMARNISSVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKF
TTRTSQKGTVAYVADETELPYDENGITPDVIINSTSIFSRKTISMLIEVI
LTAAYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDE
ELSDKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGK
KTKLIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQD
VYVCENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNA
RGVKVKLDFERRPPSFYKPLDKVDLKPSF
3D structure
PDB7ap9 Structural basis of the complete poxvirus transcription initiation process.
ChainB
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R427 Q696 H1020 R420 Q679 H987
BS02 dna B K776 K777 G1044 R1045 K1046 K759 K760 G1011 R1012 K1013
BS03 ZN B C1087 C1090 C1103 C1106 C1054 C1057 C1070 C1073
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ap9, PDBe:7ap9, PDBj:7ap9
PDBsum7ap9
PubMed34556871
UniProtQ49PH2

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