Structure of PDB 7alr Chain B

Receptor sequence
>7alrB (length=428) Species: 9913 (Bos taurus) [Search protein sequence]
REIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYY
NEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNW
AKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLL
ISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYC
IDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLR
KLAVNMVPFPRLHFFMPGFAPLTARGSQRALTVPELTQQMFDAKNMMAAC
DPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAV
CDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGM
DEMEFTEAESNMNDLVSEYQQYQDATAE
3D structure
PDB7alr Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.
ChainB
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RQK B M325 D329 K352 V353 M320 D324 K347 V348
BS02 GDP B G10 Q11 C12 Q15 S140 G143 G144 T145 G146 N206 Y224 N228 G9 Q10 C11 Q14 S137 G140 G141 T142 G143 N203 Y221 N225
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0007411 axon guidance
GO:0038007 netrin-activated signaling pathway
GO:1990791 dorsal root ganglion development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7alr, PDBe:7alr, PDBj:7alr
PDBsum7alr
PubMed33619102
UniProtQ2T9S0|TBB3_BOVIN Tubulin beta-3 chain (Gene Name=TUBB3)

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