Structure of PDB 7ala Chain B

Receptor sequence
>7alaB (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
LPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISHDE
MVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRR
LQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGNSKTVTSTMLG
VFREDPKTREEFLTLIR
3D structure
PDB7ala A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
ChainB
Resolution1.846 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C141 H144 C212 C63 H66 C134
BS02 5RW B L157 V233 T240 E243 L79 V151 T158 E161
BS03 5RW B S228 R235 R241 S146 R153 R159
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7ala, PDBe:7ala, PDBj:7ala
PDBsum7ala
PubMed33229582
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

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