Structure of PDB 7ae3 Chain B

Receptor sequence
>7ae3B (length=1097) Species: 9606 (Homo sapiens) [Search protein sequence]
APIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTS
DADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDI
EYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGG
YFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMA
VKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGP
SLEECQKAQIFTQMQALKYIGNKVRRQKTKIEEARELLASTILTHVPVKE
FNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFED
LFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS
LKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQ
WGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNL
LCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSIS
TNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFL
HESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYP
HHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTI
ELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNA
KCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQ
VLVNKSMPTVTQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLL
RQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFP
SRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLG
KDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQP
TEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGL
LGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYN
3D structure
PDB7ae3 Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q434 Q438 Q692 K904 H1014 Q409 Q413 Q667 K869 H979
BS02 dna B T707 S1040 R1046 T682 S1005 R1011
BS03 ZN B C1080 C1083 C1092 C1095 C1045 C1048 C1057 C1060
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042796 snRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ae3, PDBe:7ae3, PDBj:7ae3
PDBsum7ae3
PubMed33558764
UniProtQ9NW08|RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (Gene Name=POLR3B)

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