Structure of PDB 7aa2 Chain B

Receptor sequence

>7aa2B (length=585) Species: 759272 (Thermochaetoides thermophila DSM 1495)

NYTFIIAGGGISGLTLADRLTEDPRVTVLVIEAGPLDRGEDGILVPGAFS
PWLYFWPGLVSTPQAGLNNRTVDVITAQVVGGGSTINAMVYLRGDKDDYD
SWGALGNPGWSWNSMLPYFIKSETFTPPSPELAAAGNITWDGSIRGRSGP
VNYSYPNYFFPGSENWWNAANEVGLPPVKDPMAGSKQGVFWIPSAIDART
MTRSHARRNHYDRVSSRPNYHILPSHLVSKILFRGKQAIGVSYIPTSGGN
TTTNVYASKEITLAAGGLGTPKILQLSGIGPRKLLNELGIPVISDLPGVG
QNLQDQPTLTIPYTFTNNVFPNTDSLTTNATYNAEQRALYDSSKQGAYTI
VNSLSTNIGVMSLQRAAPKSYRQIIAAARARSASLSLPPGTDPAVIRGYQ
AQRNAILKQFENPNVGVGTVHWGTGSSALVYHLKPLSRGTVNIRSTNPLD
APEIDYRTGTDPIDAQVYTSLFRKNREIFNAPSMRVLGPSEAAPFGANLT
TDEEIYAVMRELINPSNAHQCCTAAMMPKDMGGVVSSEQKVYGVQGLRVA
DISFWPFQLSGSPMATAYAGAERLADVIKKEHRLA

3D structure

• PDB: 7aa2 Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum.
• Chain: B
• Resolution: 1.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FDA	B	G53 I56 S57 E77 A78 W101 A122 G127 G128 N132 A133 V135 L272 V273 A310 A563 H564 D596 I597 S607 P608 M609	G8 I11 S12 E32 A33 W56 A77 G82 G83 N87 A88 V90 L227 V228 A265 A518 H519 D551 I552 S562 P563 M564
BS02	EBS	B	W97 A133 V135 L399 Y476 N562 H564 S607	W52 A88 V90 L354 Y431 N517 H519 S562

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0044550 secondary metabolite biosynthetic process

External links

• PDB: RCSB:7aa2, PDBe:7aa2, PDBj:7aa2
• PDBsum: 7aa2
• PubMed: 34076590
• UniProt: G0SAW6