Structure of PDB 7a28 Chain B

Receptor sequence
>7a28B (length=332) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRL
LLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFL
YRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSAS
GNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM
AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQ
WAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPF
FQKIVDACLQGMQWTVDRIKSNRAQWERVLET
3D structure
PDB7a28 Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617
ChainB
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QWT B M785 V840 T841 Y845 M868 L870 Q874 F877 M200 V255 T256 Y260 M283 L285 Q289 F292 BindingDB: IC50=49nM
BS02 ZN B H673 H709 D710 D822 H88 H124 D125 D237
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7a28, PDBe:7a28, PDBj:7a28
PDBsum7a28
PubMed
UniProtQ8WQX9

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