Structure of PDB 6zyf Chain B

Receptor sequence
>6zyfB (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNREN
CDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSS
DVWSGASSKEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSAAGGTGVL
LNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTE
AIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLF
DEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSH
EIIIRSHWTDVQVKGTSLPRALHCWDRSLCPVHLVDSCPWPHCNPSCPT
3D structure
PDB6zyf Notum deacylates octanoylated ghrelin.
ChainB
Resolution2.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K4Q B G127 W128 A232 A233 F268 G42 W43 A143 A144 F179
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6zyf, PDBe:6zyf, PDBj:6zyf
PDBsum6zyf
PubMed33647468
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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