Structure of PDB 6zth Chain B

Receptor sequence

>6zthB (length=470) Species: 446 (Legionella pneumophila) [Search protein sequence]

TMIVIFVHGWSVTHTNTYGELPQWLENQSKQGKLDIQVGNIYLGRYISFD
DTVTVDDIARAFDQAVRDEIADKLRDGQRFACITHSTGGPIVRKWMDLYF
KNNLAKCPLSHLIMLAPANHGSALAQLGKSRLGRIKSFFEGIEPGKCVLD
WLELGSDMSWQLNESWLDYDCTANGVYSFVLTGQKIDRQFYDAVNSYTGE
SGSNGVVRVAATNMNYSLLKLHQEGDNGESLVVAKMTRTQPMAFGVLPGL
SHSGKNIGIIRSITMANAATHPTAIWILRCLQVKSRDSYNKLVKELDNIT
KETQKNEHKEFVKTLVFTREYITNRYSMIIFRLIDDRGNHLIDYDLYLTA
GPQYSEQALPAGFFVDRQRNLNNRGKLTYFLDYDIMEGGINTPKMQGNLG
FRVKAYPESSDQALAYYRLLDFHSSKILHPNETVMVEIMLQRRVDRTVFR
ISNNLTPAKISGKPTGKKID

3D structure

PDB

6zth NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB.

Chain

Resolution

2.3 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NAD	B	R187 Y190 A192 V193 S195 R318 Y320	R188 Y191 A193 V194 S196 R319 Y321
BS02	NAD	B	Y346 L347 E355 Q356 L358 A360 F363 R366	Y347 L348 E356 Q357 L359 A361 F364 R367
BS03	NAD	B	Q125 R130 N194 S195 Y196 D365	Q126 R131 N195 S196 Y197 D366
BS04	NAD	B	D344 L345 R366 R368 L376 Y378	D345 L346 R367 R369 L377 Y379

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding

View graph for
Molecular Function

External links

PDB	RCSB:6zth, PDBe:6zth, PDBj:6zth
PDBsum	6zth
PubMed	34074754
UniProt	A0A378K488

[Back to BioLiP]