Structure of PDB 6zpt Chain B

Receptor sequence

>6zptB (length=601) Species: 9606 (Homo sapiens)

QPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQE
EAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPL
AKRQQYNALLSQMSRIYSTAKVCLPQTCWSLDPDLTNILASSRSYAMLLF
AWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFE
DDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWA
QTWSNIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSP
MPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMEQLVV
VHHEMGHIQYFLQYKDLPVSLREGANPGFHEAIGDVLALSVSTPEHLHKI
GLLDRVTNDTESDINYLLKMALDKIAFLPFGYLVDQWRWGVFSGRTPPSR
YNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQ
FQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKD
MVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYP
E

3D structure

• PDB: 6zpt Angiotensin-converting enzyme open for business: structural insights into the subdomain dynamics.
• Chain: B
• Resolution: 2.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H331 A332 H361 E362 H365 E389 H491 Y501
• Catalytic site (residue number reindexed from 1): H323 A324 H353 E354 H357 E381 H483 Y493
• Enzyme Commision number: 3.4.15.1: peptidyl-dipeptidase A.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H361 H365 E389	H353 H357 E381

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6zpt, PDBe:6zpt, PDBj:6zpt
• PDBsum: 6zpt
• PubMed: 33067882
• UniProt: P12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)