Structure of PDB 6zov Chain B

Receptor sequence
>6zovB (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGSDAKEGAWPWVVGLYYDDRLLCGASLVSSDWLVSAAHCVYGRNLEP
SKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEF
KVNYTDYIQPISLPEENQVFPPGRNCSIAGWGTVVYQGTTADILQEADVP
LLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWF
LAGVTSFGYECALPNRPGVYARVSRFTEWIQSFLH
3D structure
PDB6zov Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits.
ChainB
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 D92 Q184 G185 D186 S187 G188
Catalytic site (residue number reindexed from 1) H41 D92 Q184 G185 D186 S187 G188
Enzyme Commision number 3.4.21.9: enteropeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBS B D181 S182 C183 Q184 S187 G208 E210 D181 S182 C183 Q184 S187 G208 E210
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6zov, PDBe:6zov, PDBj:6zov
PDBsum6zov
PubMed33033171
UniProtP98073|ENTK_HUMAN Enteropeptidase (Gene Name=TMPRSS15)

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