Structure of PDB 6znq Chain B

Receptor sequence

>6znqB (length=711) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIKAALSKRGID
ELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRAL
YLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHI
VITNPDMLHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIR
RLKRICRFYGSDPVFICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRK
HFVFYNPPIVNKIRRSATAEVNELAKEFLKNKVQTIVFARSRVRVEIILS
HIQELVKKEIGTKSIRGYRGGYLPKERREIERGLREGDILGVVSTNALEL
GVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGESLIIMVANSTPIDQY
IVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEEFGAMEV
SDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDI
ANVRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDV
EYYTDANLAVQLKIDKTDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEE
LHTSAAWLETLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGL
PTIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTK
AKERILQLLDQ

3D structure

• PDB: 6znq A skipping rope translocation mechanism in a widespread family of DNA repair helicases.
• Chain: B
• Resolution: 3.34 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	T108 K109 Y135 G137 R144 N157 D159 M160 S163 A164 H168 K171 S297 R298 R325 G326 R333 T351 N352 A353 F483 S489 R491 N666	T105 K106 Y132 G134 R141 N154 D156 M157 S160 A161 H165 K168 S291 R292 R319 G320 R327 T345 N346 A347 F477 S483 R485 N635
BS02	ZN	B	C718 C724 C727	C687 C693 C696
BS03	ANP	B	I52 Y56 Q59 T78 A79 G81 K82 T83	I49 Y53 Q56 T75 A76 G78 K79 T80

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0043138 3'-5' DNA helicase activity

Biological Process

• GO:0006289 nucleotide-excision repair
• GO:0032508 DNA duplex unwinding
• GO:0036297 interstrand cross-link repair

External links

• PDB: RCSB:6znq, PDBe:6znq, PDBj:6znq
• PDBsum: 6znq
• PubMed: 33300032
• UniProt: P50830|YPRA_BACSU Uncharacterized ATP-dependent helicase YprA (Gene Name=yprA)