Structure of PDB 6zng Chain B

Receptor sequence
>6zngB (length=748) Species: 264462 (Bdellovibrio bacteriovorus HD100) [Search protein sequence]
TNFDQEALLYHQQGKPGKIEVISSKPCATEKDLSLAYSPGVAAPCKAIAK
DPAKVYDYTAKGNLVAVISNGTAVLGLGNIGPAAGKPVMEGKGILFKQFA
GIDVFDIEVAATDVDVFCNAVRVLEPTFGGINLEDIKAPECFEIEERLKK
EMNIPVFHDDQHGTAIVSGAALLNACSITNRKMETVRIVVNGAGASANSC
AKIFIALGARRENIIMCDSQGVIYKGRTAGMNKYKEYFASETEARTLTEA
LRGADVFVGLSVAGALTPEMLKDMAKDPIIFAMANPEPEITPDKARAARP
DAIIATGRSDYPNQVNNVLGFPSIFRGALDTRSTQINEEMKLAAVHALAK
LAREDFKFGRDYLIPKPFDTRVLLWVAPEVAKAAMKSGVATRAIEDWDQY
RESLEALQGPSKVFIRSAINRVHQNSAANGGELPRIVFPEGTSTKVLKAL
ATLVEEKICQPILLGYPERVKEKIKALDIPLLNDVSIVHPSSHPKYFSFV
EKLYSLRQRKGINLGEAERLMADPNYFAAMMVNQGEADGMVSGSSINYAD
AVRPILQTIGVYKEGIPAGLNFVLLEDKFLVLADTTVNLNPTAEQCAQIA
LQAAKIVEYFGIEPRVAMLSYSNFSGAEGTPRKMKKAAEIARSLRPDLMI
EGDMQADTAVNPEIMERLFPFSGLKGGANVLVFPNLESSNIAYKLIQQIG
KAEVIGPFLTGVRRSANVLQRTTTVDGIVNSVVFTALEAQYIKEVLKS
3D structure
PDB6zng A rotary mechanism for allostery in bacterial hybrid malic enzymes.
ChainB
Resolution2.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y52 A88 K107 E149 D150 D174 D175 N300
Catalytic site (residue number reindexed from 1) Y37 A73 K92 E134 D135 D159 D160 N285
Enzyme Commision number 1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO B Y649 Q683 Y621 Q655
BS02 ACO B R535 K538 Y576 R581 L584 P595 T614 V615 N616 N718 K722 Q748 R507 K510 Y548 R553 L556 P567 T586 V587 N588 N690 K694 Q720
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004470 malic enzyme activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6zng, PDBe:6zng, PDBj:6zng
PDBsum6zng
PubMed33623032
UniProtQ6MM14;
Q6MM15

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