Structure of PDB 6zn7 Chain B

Receptor sequence
>6zn7B (length=411) Species: 264462 (Bdellovibrio bacteriovorus HD100) [Search protein sequence]
TTNFDQEALLYHQQGKPGKIEVISSKPCATEKDLSLAYSPGVAAPCKAIA
KDPAKVYDYTAKGNLVAVISNGTAVLGLGNIGPAAGKPVMEGKGILFKQF
AGIDVFDIEVAATDVDVFCNAVRVLEPTFGGINLEDIKAPECFEIEERLK
KEMNIPVFHDDQHGTAIVSGAALLNACSITNRKMETVRIVVNGAGASANS
CAKIFIALGARRENIIMCDSQGVIYKGRTAGMNKYKEYFASETEARTLTE
ALRGADVFVGLSVAGALTPEMLKDMAKDPIIFAMANPEPEITPDKARAAR
PDAIIATGRSDYPNQVNNVLGFPSIFRGALDTRSTQINEEMKLAAVHALA
KLAREDVPDKVSATYGGKSFKFGRDYLIPKPFDTRVLLWVAPEVAKAAMK
SGVATRAIEDW
3D structure
PDB6zn7 A rotary mechanism for allostery in bacterial hybrid malic enzymes.
ChainB
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y52 A88 K107 E149 D150 D174 D175 N300
Catalytic site (residue number reindexed from 1) Y38 A74 K93 E135 D136 D160 D161 N286
Enzyme Commision number 1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E149 D150 D175 E135 D136 D161
BS02 NAP B T179 N206 A208 G209 A210 S211 D233 S234 K250 L275 S276 M298 N300 V330 T165 N192 A194 G195 A196 S197 D219 S220 K236 L261 S262 M284 N286 V316
Gene Ontology
Molecular Function
GO:0004470 malic enzyme activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6zn7, PDBe:6zn7, PDBj:6zn7
PDBsum6zn7
PubMed33623032
UniProtQ6MM14;
Q6MM15

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