Structure of PDB 6zmk Chain B

Receptor sequence
>6zmkB (length=656) Species: 9606 (Homo sapiens) [Search protein sequence]
CGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWE
ANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGE
PSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTET
IAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGT
RRGSPLLIGVRSEHKLSTDHIPILYRDSTTCLFPVEEKAVEYYFASDASA
VIEHTNRVIFLEDDDVAAVVDGRLSIHRRAVQTLQMELQQIMKGNFSSFM
QKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACG
TSYHAGVATRQVLEELTELPVMVELASDFRDRNTPVFRDDVCFFLSQSGE
TADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVAST
KAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDD
EIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGEL
KHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDT
ETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLA
KSVTVE
3D structure
PDB6zmk Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1.
ChainB
Resolution2.382 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L8 R33 W96 N123 G124 E554 K558 E561 H577 K676
Catalytic site (residue number reindexed from 1) L7 R32 W95 N122 G123 E529 K533 E536 H552 K651
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6Q B T376 S377 S421 Q422 S423 T426 S474 K558 E561 T351 S352 S396 Q397 S398 T401 S449 K533 E536
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
GO:1901137 carbohydrate derivative biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6zmk, PDBe:6zmk, PDBj:6zmk
PDBsum6zmk
PubMed33846315
UniProtQ06210|GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (Gene Name=GFPT1)

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