Structure of PDB 6zjz Chain B

Receptor sequence
>6zjzB (length=740) Species: 9606 (Homo sapiens) [Search protein sequence]
FSRSYPCDEKVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQ
GLTKINLNHNPNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTE
LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETL
TNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTL
LDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIK
GSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTIN
LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVFDPHSNFYHFTRPLIK
PQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEF
SAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHH
LEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWND
DDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNML
KFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISH
LPSGFLSEVSSLKHLDLSSNLLKTINKSALKLSMLELHGNPFECTCDIGD
FRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTC
3D structure
PDB6zjz Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity.
ChainB
Resolution2.489 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QLH B F494 F495 A518 Y567 F418 F419 A442 Y491 MOAD: ic50=120nM
BS02 QLH B F346 Y348 K350 G351 S352 G376 V378 I403 F405 F296 Y298 K300 G301 S302 G326 V328 I353 F355 MOAD: ic50=120nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zjz, PDBe:6zjz, PDBj:6zjz
PDBsum6zjz
PubMed33328334
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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