Structure of PDB 6z6i Chain B

Receptor sequence
>6z6iB (length=173) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
VNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGA
LNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNK
GEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVY
LAVFDKNLYDKLVSSFLEMKSEK
3D structure
PDB6z6i Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R B D226 I227 A242 N244 G251 G252 V253 L330 S332 A333 G334 I335 F336 A358 F360 D20 I21 A36 N38 G45 G46 V47 L124 S126 A127 G128 I129 F130 A152 F154
External links
PDB RCSB:6z6i, PDBe:6z6i, PDBj:6z6i
PDBsum6z6i
PubMed33202171
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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