Structure of PDB 6z4b Chain B

Receptor sequence
>6z4bB (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
PNQALLRILKETEFKKIKVLGSGTVYKGLWIPEKVKIPVAIKELREATSP
KANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVR
EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI
TDFGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS
EISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKM
ARDPQRYLVIQGD
3D structure
PDB6z4b Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D837 R841 N842 D855
Catalytic site (residue number reindexed from 1) D134 R138 N139 D152
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q6K B L718 V726 A743 M790 L792 M793 P794 G796 C797 D800 L844 D855 L20 V25 A40 M87 L89 M90 P91 G93 C94 D97 L141 D152
BS02 9LL B V726 A743 K745 I759 E762 M766 R776 L777 L788 D855 F856 V25 A40 K42 I56 E59 M63 R73 L74 L85 D152 F153 BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z4b, PDBe:6z4b, PDBj:6z4b
PDBsum6z4b
PubMed33335671
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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