Structure of PDB 6z2f Chain B

Receptor sequence
>6z2fB (length=475) Species: 9606 (Homo sapiens) [Search protein sequence]
INDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKA
IEGFVDARMEPVPLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKG
MYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMES
TKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGN
GGLYRTLAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGA
DCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLF
NAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVQGQLIKPDKPNG
IKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHAL
MSLHHCWVLNAGGHFIDENGSRLPAIPRLKDANDVPIQCEISPLISYAGE
GLESYVADKEFHAPLIIDENGVHEL
3D structure
PDB6z2f Crystal structure of human AGX1 mutant complexed with UDPGLCNAC
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.-
2.7.7.23: UDP-N-acetylglucosamine diphosphorylase.
2.7.7.83: UDP-N-acetylgalactosamine diphosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD1 B G110 G111 Q112 G113 R115 K122 N223 V289 G290 E303 Y304 N327 F383 K407 G87 G88 Q89 G90 R92 K99 N200 V266 G267 E280 Y281 N304 F358 K382
Gene Ontology
Molecular Function
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
GO:0052630 UDP-N-acetylgalactosamine diphosphorylase activity
GO:0070569 uridylyltransferase activity
GO:0141090 protein serine pyrophosphorylase activity
Biological Process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z2f, PDBe:6z2f, PDBj:6z2f
PDBsum6z2f
PubMed
UniProtQ16222|UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase (Gene Name=UAP1)

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