Structure of PDB 6yvj Chain B

Receptor sequence

>6yvjB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]

SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG
EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG
GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDR
PFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKME
DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLY
VWDLECTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR

3D structure

PDB

6yvj Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.

Chain

Resolution

1.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EJR	B	F97 Y148 N194 K211 D310 Y365 M366 R367 R414	F17 Y68 N114 K131 D223 Y278 M279 R280 R319

External links

PDB	RCSB:6yvj, PDBe:6yvj, PDBj:6yvj
PDBsum	6yvj
PubMed	33684441
UniProt	O75530\|EED_HUMAN Polycomb protein EED (Gene Name=EED)

[Back to BioLiP]