Structure of PDB 6ysn Chain B

Receptor sequence
>6ysnB (length=606) Species: 9606,83333 [Search protein sequence]
RIPLQIVRAETELSAEEKAFVNINCMDPLGRSALLIAIENENLYVGDALL
YAIRKEVVGAVELLLSQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTI
PRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPIL
TAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEII
LNHRDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKL
LTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFML
LLASQDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGYIHDWWNLMD
FAMNSLYLATISLKIMAYVKYNGSRPREEWEMWHPTLIAEALFAISNILS
SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLY
FYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTN
VKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW
KFARTKLWMSYFDEGGTLPPPFNIINADSLIQNQHYQEVIRNLVKRYVAA
MIRNSK
3D structure
PDB6ysn Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PJQ B Y524 C525 Q573 F576 Y435 C436 Q484 F487
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Cellular Component
External links
PDB RCSB:6ysn, PDBe:6ysn, PDBj:6ysn
PDBsum6ysn
PubMed33230284
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)

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