Structure of PDB 6yom Chain B

Receptor sequence

>6yomB (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIINTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRR
AYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKL
TDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKRED
YESLPKEVAKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRI
TKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQ
DGDVIAPLITPQKKEW

3D structure

PDB

6yom Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

3.25 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CZF	B	Y155 V156 V378 R451	Y41 V42 V256 R329
BS02	DTP	B	I118 N119 H125	I4 N5 H11
BS03	DTP	B	V156 F157 R372 H376 K377	V42 F43 R250 H254 K255
BS04	FE	B	H167 H206 D207 D311	H53 H92 D93 D189
BS05	MN	B	H206 D207 H233	H92 D93 H119
BS06	0KX	B	Q149 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q35 R50 D93 H101 H119 D189 K190 Y193 D197 R244 Y252
BS07	CZF	B	K116 V117 I118 N137 Q142 R145	K2 V3 I4 N23 Q28 R31

External links

PDB	RCSB:6yom, PDBe:6yom, PDBj:6yom
PDBsum	6yom
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]