Structure of PDB 6yky Chain B

Receptor sequence
>6ykyB (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALRE
IKIIRRLDHDNIVKVFEILGPSGSQLTTELNSVYIVQEYMETDLANVLEQ
GPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGD
FGLARIMDPHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLT
GKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVMTEPHKPLTQLL
PGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF
3D structure
PDB6yky Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors.
ChainB
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D152 K154 N157 D171 T194
Catalytic site (residue number reindexed from 1) D131 K133 N136 D150 T167
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OWQ B L26 G27 C28 V34 A47 Y110 M111 T113 N117 F159 L11 G12 C13 V19 A32 Y89 M90 T92 N96 F138
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yky, PDBe:6yky, PDBj:6yky
PDBsum6yky
PubMed32927028
UniProtQ16659|MK06_HUMAN Mitogen-activated protein kinase 6 (Gene Name=MAPK6)

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