Structure of PDB 6yg6 Chain B

Receptor sequence
>6yg6B (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
GYLTIGGQRYQAEINDLENLGEMGGQVWKMRFRKTGHVIAVKQMRRSGNK
EENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLK
KRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI
KLCDFGGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPY
KNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN
KLLEHSFIKRYETLEVDVASWFKDVMAKTES
3D structure
PDB6yg6 Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D259 K261 N264 D277 C296
Catalytic site (residue number reindexed from 1) D136 K138 N141 D154 C158
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OQ8 B K165 D182 V186 V196 M212 M215 C218 V255 I256 H257 C276 D277 F278 K42 D59 V63 V73 M89 M92 C95 V132 I133 H134 C153 D154 F155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yg6, PDBe:6yg6, PDBj:6yg6
PDBsum6yg6
PubMed32783966
UniProtO14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (Gene Name=MAP2K7)

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