Structure of PDB 6ycc Chain B

Receptor sequence
>6yccB (length=215) Species: 4615 (Ananas comosus) [Search protein sequence]
VPQSIDWRDSGAVTSVKNQGRCGSCWAFASIATVESIYKIKRGNLVSLSE
QQVLDCAVSYGCKGGWINKAYSFIISNKGVASAAIYPYKAAKGTCKTNGV
PNSAYITRYTYVQRNNERNMMYAVSNQPIAAALDASGNFQHYKRGVFTGP
CGTRLNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIRLARDVSSSF
GLCGIAMDPLYPTLQ
3D structure
PDB6ycc Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
ChainB
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H157 N178
Catalytic site (residue number reindexed from 1) Q19 C25 H157 N178
Enzyme Commision number 3.4.22.31: ananain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E64 B Q19 G23 C25 W26 Y60 K63 G64 G65 N156 H157 A158 Q19 G23 C25 W26 Y60 K63 G64 G65 N156 H157 A158
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ycc, PDBe:6ycc, PDBj:6ycc
PDBsum6ycc
PubMed33177555
UniProtP80884|ANAN_ANACO Ananain (Gene Name=AN1)

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