Structure of PDB 6y91 Chain B

Receptor sequence
>6y91B (length=302) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
TKIALIGSGQIGAIVGELCLLENLGDLILYDVVPGIPQGKALDLKHFSTI
LGVNRNILGTNQIEDIKDADIIVITAGVLIGVNGKIMKSVAESVKLHCSK
AFVICVSNPLDIMVNVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKV
SAEDVNAVILGGHGDLMVPLQRYTSVNGVPLSEFVKKNMISQNEIQEIIQ
KTRNMGAEIIKLAKASAAFAPAAAITKMIKSYLYNENNLFTCAVYLNGHY
NCSNLFVGSTAKINNKGAHPVEFPLTKEEQDLYTESIASVQSNTQKAFDL
IK
3D structure
PDB6y91 A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G10 I12 D32 V33 T76 A77 G78 I97 V117 N119 M142 L146 H174 G9 I11 D31 V32 T75 A76 G77 I86 V106 N108 M131 L135 H163
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6y91, PDBe:6y91, PDBj:6y91
PDBsum6y91
PubMed34376783
UniProtQ6VVP7

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