Structure of PDB 6y8l Chain B

Receptor sequence
>6y8lB (length=179) Species: 1797 (Mycolicibacterium thermoresistibile) [Search protein sequence]
GLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGHATKVRVRLLA
DGGVEVSDDGRGIPVEMGVPTVDVVMTQVGVSVVNALSTRMEVEICRDGY
QWFQTYDKSVPGTLKQGEKTRKTGTVVRFWPDPDVFETTTFDFETVARRL
QEQAFLNKGLTIELIDERDGKHRTFYYPG
3D structure
PDB6y8l Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
ChainB
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D51 D55 D30 D34
BS02 NOV B N52 R82 I84 P85 V99 R141 N31 R61 I63 P64 V75 R97
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6y8l, PDBe:6y8l, PDBj:6y8l
PDBsum6y8l
PubMed32728686
UniProtG7CIP8

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