Structure of PDB 6y2x Chain B

Receptor sequence
>6y2xB (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
PEPEQVIKNDEDCIICEKLSTASTDSKAIGSLAVLTKCSHHLLCLLAMYC
NKDGSLQCPSCKTEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPR
GFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTVVWNEIHHKTE
MDRGHGYPDPNYLQNVLAELAAQGVTE
3D structure
PDB6y2x DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
ChainB
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H447 C469 H40 C58
BS02 ZN B C412 H450 C453 C13 H41 C44
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6y2x, PDBe:6y2x, PDBj:6y2x
PDBsum6y2x
PubMed32937373
UniProtQ86UW9|DTX2_HUMAN Probable E3 ubiquitin-protein ligase DTX2 (Gene Name=DTX2)

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