Structure of PDB 6xxq Chain B

Receptor sequence
>6xxqB (length=248) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
NTYEQINKVKKILRKHLKNNLIGTYMFGSGVESGLKPNSDLDFLVVVSEP
LTDQSKEILIQKIRPISKKIGDKSNLRYIELTIIIQQEMVPWNHPPKQEF
IYGEWLQELYEQGYIPQKELNSDLTIMLYQAKRKNKRIYGNYDLEELLPD
IPFSDVRRAIMDSSEELIDNYQDDETNSILTLCRMILTMDTGKIIPKDIA
GNAVAESSPLEHRERILLAVRSYLGENIEWTNENVNLTINYLNNRLKK
3D structure
PDB6xxq Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.47: streptomycin 3''-adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S35 D46 D48 S29 D40 D42
BS02 ATP B G34 S35 S45 D46 D48 D129 I132 M133 Q136 R190 M191 T194 I200 K203 Y229 G28 S29 S39 D40 D42 D123 I126 M127 Q130 R184 M185 T188 I194 K197 Y223
BS03 SCM B E86 W111 D180 N183 E80 W105 D174 N177
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0009012 aminoglycoside 3''-adenylyltransferase activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6xxq, PDBe:6xxq, PDBj:6xxq
PDBsum6xxq
PubMed32253216
UniProtQ07448|S9AD_ENTFL Spectinomycin 9-adenylyltransferase (Gene Name=spc)

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