Structure of PDB 6xv6 Chain B

Receptor sequence
>6xv6B (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
DKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPD
FRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQ
NVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATG
RLCTVAACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQI
RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHL
GLEIPAWDGPRVLERALPPLPRPPTPKLE
3D structure
PDB6xv6 Binding site for activator MDL-801 on SIRT6.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P62 D63 F64 R65 N114 D116 H133
Catalytic site (residue number reindexed from 1) P49 D50 F51 R52 N101 D103 H120
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 B G52 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258 G39 G41 T44 D50 F51 R52 Q100 H120 G195 T196 S197 I200 N221 L222 Q223 Y238 V239
BS02 ZN B C141 C144 C166 C177 C128 C131 C153 C158
BS03 NCA B I61 P62 F64 F86 N114 V115 D116 I48 P49 F51 F73 N101 V102 D103 BindingDB: IC50=120000nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6xv6, PDBe:6xv6, PDBj:6xv6
PDBsum6xv6
PubMed33649599
UniProtQ8N6T7|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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